The start point of the race is near Hemiciclo a Juárez in Alameda Central. The course takes a south-to-north loop on Paseo de la Reforma, then follows another loop back, passing Torre Mayor twice. The final part of the race follows Avenida de los Insurgentes westwards to reach the end-point at Estadio Olímpico Universitario. The course overall is slightly uphill with a total rise of around 65 metres. It is largely flat at the beginning, has a hilly section between 10 km and 25 km, and ends with an incline in the final ten kilometres.

The point-to-point course has approximately 614 feet (187 meters) of total elevation gain and 798 feet (243 meters) of total elevation loss, resulting in a net downhill profile.